Lymphoma and Myeloma

Lymphoma is complex - this video lecture makes things a little easier.

 

Lecture by

Video Duration: 14 minutes

  • Lymphoma
    Created by Dr Ed Wallitt
    General
    Epidemiology

    "General proliferation of lymphocytes"

    M>F. Bimodal incidence: 20-29 and > 60y

    Pathology

    Two main types

    • Hodgkin's (80%) - small number of malignant cells in lymph nodes with lots of reactive lymphocytes, macrophages and plasma cells
    • Non-Hodgkin's (20%) (low grade, high grade, MALT and EATL)
    Top three causes

    Unknown. May be associated with EBV

    Clinical Features
    Symptoms

    Painlesss swelling of a lymph node

    B symptoms - Fever, weight loss and night sweats

    Signs

    Lymphadenopathy

    Splenomegaly/hepatomegaly

    Investigations
    Cultures

    None

    Bloods

    FBC (reduce HB and lymphocytosis), ESR (worse prognosis), LFTs, LDH (worse prognosis )

    Imaging

    Staging with CT +/- PET (chest, abdomen and pelvis)

    Scopic/Biopsy

    Lymph node excision and biopsy

    Bone marrow aspirate/trephine

    Functional

    None

    Treatment
    Conservative

    Supportive treatment and staging

    Medical

    Chemotherapy +/- radiotherapy (e.g. ABVD or R-CHOP)

    Surgical

    Lymph node excision